
Why Mushrooms?
"Psilocybin and Mental Health: Unveiling the Therapeutic Potential of Mushrooms"
Harnessing Fungi for Health: The Potential of Psilocybin
For centuries, humans have leveraged fungi’s metabolic products for medicinal purposes, such as penicillin. Recently, psilocybin, another fungal metabolite, has drawn significant interest from the media, clinicians, and researchers. Found naturally in numerous mushroom species known as “magic mushrooms,” psilocybin interacts with serotonin receptors in the brain to produce various psychedelic effects.
A growing body of research indicates that when psilocybin is administered under controlled conditions with supportive therapy, it may help treat psychiatric disorders like depression. However, questions about its mechanism, stigma, funding, and regulatory challenges need addressing before it can be widely used therapeutically.
Understanding Psilocybin and Its Effects
Psilocybin is produced by over 200 species of basidiomycete fungi, known collectively as psilocybin mushrooms, found worldwide. It can also be synthesized and administered in standardized doses, typically used in clinical settings.
Psilocybin belongs to the serotonergic psychedelics class, which includes LSD and mescaline. Its effects vary by person and dose, potentially causing euphoria, altered perception, spiritual experiences, and detachment. These effects stem from psilocin, the active metabolite of psilocybin, which activates serotonin 5-HT2a receptors on cortical pyramidal cells in the brain, influencing cognitive function and perception.
The History of Psilocybin Research
Psilocybin mushrooms have been used for centuries in Central America. However, they remained largely unknown in the West until the 1950s, when American mycologist R. Gordon Wasson documented his experience with them in a 1957 Life magazine article. That same year, chemist Albert Hofmann isolated psilocybin, leading Sandoz Pharmaceuticals to produce psilocybin pills for research.
Research flourished in the 1960s but declined after the DEA classified psilocybin as a Schedule I drug in 1970, imposing stringent research restrictions. Recently, however, interest has revived, supported by philanthropists and organizations like the Heffter Research Institute. Modern studies at institutions across the U.S. are exploring psilocybin’s potential for various medical conditions.
The Clinical Promise of Psilocybin
Research suggests psilocybin, when administered under medical supervision, may treat psychiatric conditions like OCD, alcohol and substance use disorders, and depression. Clinical trials have shown its effectiveness in reducing depression symptoms, including treatment-resistant depression, with effects lasting from weeks to months.
The Benefits and Risks of Psilocybin Treatment
Psilocybin’s rapid onset and prolonged effects make it a promising alternative to traditional antidepressants, which often take weeks to work. However, it is not effective for everyone and can pose risks, particularly for individuals predisposed to psychosis. Common side effects include headache, nausea, and fatigue.
Despite these challenges, ongoing research and clinical trials are crucial for understanding psilocybin’s full potential and navigating the regulatory landscape. Although widespread prescription use may not be imminent, controlled therapeutic applications hold promise for the future.
Microdosing
Benefits of Microdosing
Microdosing enthusiasts report various benefits, including:
- Increased focus, creativity, productivity, and energy.
- Reduced anxiety, depression, or stress.
- Lowered social anxiety.
- Alleviated menstrual pain.
- Improved emotional openness.
- Enhanced spiritual awareness.
- Reduced cravings for addictive substances.
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How to Start Microdosing
If you want to start microdosing (whether it’s mushrooms or another substance), here are your first three steps:
1. Research and Education
Before beginning microdosing, thorough knowledge is essential. Study the substance you intend to use, including its effects, potential risks, and legal status. Rely on trustworthy sources and scientific research.
2. Set Clear Intentions
Define your goals for microdosing. Whether aiming for enhanced creativity, a better mood, or increased focus, having clear intentions will guide your journey and help you evaluate the effectiveness of microdosing for your specific needs.
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How Much to Microdose?
Determining the right dosage is crucial for a successful microdosing experience. Keep in mind that individual tolerance varies, so it's wise to start on the lower end and gradually adjust based on your body's response.
In most research, the therapeutic dose of psilocybin for macrodosing (full dose) ranges from 20 to 30 mg/70 kg of body weight. For a person who weighs around 150 pounds, that’s approximately 20-30 milligrams.
Following the “one-tenth” rule for microdosing, a 150-pound person should take around 2-3 milligrams of psilocybin. Some self-report studies have used doses as low as 20 micrograms.
Remember, this is the amount of psilocybin needed—not the amount of mushrooms by dry weight. Different species of psilocybin mushrooms have varying potencies. On average, they contain about 1% psilocybin by dry weight. Thus, 1 gram of dry mushrooms may contain around 10 milligrams of psilocybin. Some microdosing studies involve a dose of 0.5 grams of dried psilocybin mushrooms, or approximately 5 milligrams of psilocybin, with positive results.
Macrodose aka "The Heroic Dose"
Heroic dosers claim to travel to different dimensions and explore new depths of their subconscious mind. We asked the experts for a roadmap through hyperspace.
Article by Suzannah Weiss - Published on November 11, 2022
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“The journey of the hero is about the courage to seek the depths; the image of creative rebirth; the eternal cycle of change within us; the uncanny discovery that the seeker is the mystery which the seeker seeks to know.”
—Joseph Campbell
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There’s no doubt that psilocybin mushrooms can inspire powerful, unique, and transformative experiences. Research suggests that these psychedelic fungi can occasion lasting changes in personality, as well as reduce depression and anxiety, particularly for those facing end-of-life distress. In a clinical setting, many of these outcomes are inspired by high doses of psilocybin—but dosing is different from person to person, and the effects of psilocybin can vary quite drastically between different dosage brackets.
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Ethnobotanist Terence McKenna popularized the term “heroic dose” in the 1980s, referring to five grams of dried Psilocybe cubensis mushrooms—an extra high dose. Unlike high doses—which hover at around 3.5 grams or so—heroic doses are strong enough to take you out of your present reality. Some cultural traditions and dedicated individuals find meaning in such powerful experiences.
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Yet, before proceeding, it’s vital to mention: heroic dosing isn’t always fun and games, and psychedelics are not for everyone. Magic mushrooms can be challenging and deeply confusing, and there are no guarantees of any specific outcome. It can be difficult to care for yourself during a heroic dose. As such, journeying in a safe and supportive environment is essential. Because these journeys can bring up strong emotions, it’s important also to leave time to process the experience aftward. Some may find it helpful to reach out to a coach, guide, therapist, or friend to help you “integrate” your psychedelic journey—especially if it was frightening or challenging.
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What is a Heroic Dose?
According to McKenna, the term “heroic dose,” means five grams of dried Psilocybe cubensis mushrooms taken alone in the dark with closed eyes. The purpose of the darkness is to explore one’s own mind free from distractions—though the concept has been adapted to include journeys under the guidance of a facilitator, as taking such a dose alone can be dangerous.
A heroic dose is generally one that is sufficient for experiencing a breakthrough, says Shane Norte, founder, leader of the Church Of The People For Creator and Mother Earth and board member of Decriminalize Nature National, who has guided people on journeys with heroic doses of mushrooms. “It’s transformative, reconnecting, scary, ego-shattering, life-changing, horrible, and beautiful all in one dose,” he says, adding that people may feel led to take a heroic dose due to difficult times in their life (such as the death of a loved one), mental health or addiction issues, or the desire for self-discovery.
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How Much Is a Heroic Dose of Mushrooms?
The threshold for how high a dose is needed to experience a heroic effect varies from person to person. However, Norte and James Giordano, professor of neurology and biochemistry at Georgetown University Medical Center, agree that a heroic dose of mushrooms is usually five grams or more taken in one sitting. But it can be up to 15 grams or more, which Norte calls a “Wamkish dose.” The more experience you have with mushrooms, the more you will need to take to get a strong effect, Giordano says.
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If you do not have a lot of experience with mushrooms, Giordano recommends gradually working your way up rather than trying to go from a small dose to a heroic dose. For instance, someone who has taken two grams of mushrooms before might try four grams next to see how that affects them. “There’s no set absolute limit as to what constitutes ‘well, you’re not a tripping hero unless you do X,’” he says.
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How Long Does a Heroic Dose Last?
Mushrooms tend to last for 5 to 6 hours but can last longer at high doses, says Giordano. A heroic dose contains three phases, he explains: the “blast off,” which usually happens within two hours; the strongest or peak experience, which occurs from around 3 to 5 hours into the trip; and the comedown and reflection period at the end.
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Why Do They Call It A Heroic Dose?
The term “heroic dose” is a reference to the “hero’s journey”—a journey undertaken in mythology that involves deep transformation, working through a crisis, and returning home, says Giordano. It is thought that when someone takes a heroic dose, they go on a hero’s journey into their own mind, potentially resolving long-standing conflicts and emerging with a stronger sense of who they are.
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Safe Heroic Dosing
“Heroism is not the same as recklessness, nor is it the same as fearlessness,” says Giordano. In other words, being cautious doesn’t take away from a heroic dose and is, in fact, essential.
“Many describe their experiences of high-dose psychedelics as beautiful and life-changing, but far too commonly, people report traumatic experiences that set them into an anxious pattern,” says psychiatrist Sam Zand, founder of the Anywhere Clinic and co-founder and chief medical officer for Better U. “The key is having proper guidance.”
Giordano urges heroic dosers to make sure someone else is with them, or at least easily reachable, in case they have a bad trip and start to spiral. Even if someone wants to honor McKenna’s original prescription to journey alone, “‘alone’ doesn’t mean you’re not without rescue,” says Giordano. “It could be you’re in a room and someone is in the next room, so if you feel the trip is going badly, you have someone who has access to you fairly quickly.”
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What To Expect from a Heroic Dose
A heroic dose creates “a psychedelic experience that draws us closer to our subconscious and unconscious thoughts,” says Zand. “We see ourselves often from an outside perspective and can find enlightenment where there were previous blind spots. With proper therapeutic preparation and post-session integration, we can use this experience to enact new patterns of thinking and feeling in our future.”
If you have taken a smaller dose of mushrooms before, you can expect a heroic dose to involve the same effects you experienced—both positive and negative—but more strongly, says Giordano. Negative effects may include nausea, agitation, restlessness, and anxiety.
The positive effects of taking a heroic dose can include “traveling to different dimensions, losing sense of time and space, rekindling the relationship to nature, accepting things that are beyond oneself or others, and knowing you have a beautiful part within creation—and that you have the power to change in a good way,” says Norte. You should know it can get difficult, he says, but remember that a professional facilitator is trained to support you through difficult moments.
Matt Zemon, author of Psychedelics for Everyone, remembers becoming “aware of my grandparents, great-grandparents, and all of the people I was connected to in this world” during a heroic dose. He elaborates, “I felt connected to the Earth, trees, and sky in a way I had never felt before. And I felt loved. Unconditionally loved. And I realized I was safe.”
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How To Prepare for A Psilocybin Experience
Before doing something as significant as taking a heroic dose of mushrooms, Norte recommends getting clear on why you want to do it and what you hope to get out of it.
Zand recommends breathwork, meditation, and journaling as ways to relax and set intentions for a psychedelic experience. Nayo Washington encourages you to “take time for mindful preparation with safety and comfort in mind.”
Dennis McKenna, brother of the late Terence McKenna, explains the importance of set and setting in an interview: “Do it in a place where no one is going to bother you—no one, at least, that you don’t want to bother you.”
He recommends a significant other be present, perhaps, and encourages travelers to remain mindful of their mental state before the trip. “The set is everything you bring to it: who you are, what your expectation is, it’s everything. It’s you. It’s your mindset.”
To create a calming environment and lessen the chances of a bad trip, Giordano recommends selecting relaxing music that you can play during the trip. It’s also a good idea to be in a cool room or have a fan or cold water with you since some people feel very hot when they trip, he adds.
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How Long Should You Wait Between Mushroom Doses?
Since there isn’t any research indicating how often it is safe to experience a heroic dose, Zand recommends being conservative about this. Norte urges waiting at least two or three weeks between heroic doses in order to rest and rejuvenate yourself.
Terence McKenna also advocated for infrequent doses. “Sometimes people are disappointed because they ask: ‘Well, how often do you do it?’ he said in an old recorded interview. “The answer is not very often. I mean if I can get it in a couple to three times a year, I feel like I’m hitting it very hard.”
“The more successful it is, the less often you have to do it,” he says.
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Integrating After a Heroic Experience
There are many ways to integrate a heroic dose of mushrooms, or any plant medicine experience. In the Church Of The People For Creator and Mother Earth, people go into sweat lodges to reflect on their experiences, says Norte. (You will want to make sure you are well-hydrated before entering a sweat lodge, though.)
A more common way to integrate is by jotting down insights from your experience in a journal, says Zand. If you journaled beforehand, you can revisit your intentions or questions and see what came to you in your trip that is relevant.
Lastly, you will get more out of the journey if you speak with a therapist or psychedelic integration specialist about it afterward. “It is important to do this work with a professional who can guide the medicine and coach you through the integration,” Zand says.
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